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1

Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2

Zak, Krzysztof M., Grudnik, Przemyslaw, Magiera, Katarzyna, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.

Journal:

Year:

2017

Language:

english

File:

PDF, 2.93 MB

english, 2017

2

Structure of the Stapled p53 Peptide Bound to Mdm2

Baek, Sohee, Kutchukian, Peter S., Verdine, Gregory L., Huber, Robert, Holak, Tad A., Lee, Ki Won, Popowicz, Grzegorz M.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 3.26 MB

english, 2012

3

Conformations of Peptide Fragments Comprising the Complete Sequence of Component III of Chi t I and Their Relationship to T-Cell Stimulation

Czisch, Michael, Liebers, Verena, Bernstein, Reimond, Chen, Zhiping, Baur, Xaver, Holak, Tad A.

Journal:

Year:

1994

Language:

english

File:

PDF, 2.24 MB

english, 1994

4

Artificial macrocycles as potent p53-MDM2 inhibitors

Estrada-Ortiz, Natalia, Neochoritis, Constantinos G., Twarda-Clapa, Aleksandra, Musielak, Bogdan, Holak, Tad A, Dömling, Alexander

Journal:

ACS Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 702 KB

english, 2017

5

Multicomponent Peptide Stapling as a Diversity‐Driven Tool for the Development of Inhibitors of Protein‐Protein Interactions

Doemling, Alexander, Ricardo, Manuel, Ali, Ameena, Plewka, Jacek, Surmiak, Ewa, Labuzek, Beata, Neochoritis, Constantinos, Atmaj, Jack, Skalniak, Lukasz, Zhang, Ran, Holak, Tad, Groves, Matthew, River

Journal:

Angewandte Chemie

Year:

2020

Language:

english

File:

PDF, 1.49 MB

english, 2020

6

Conformation of thymosin β9 in water/fluoroalcohol solution determined by NMR spectroscopy

Raphael Stoll, Wolfgang Voelter, Tad A. Holak

Journal:

Year:

1997

Language:

english

File:

PDF, 331 KB

english, 1997

7

Robust Generation of Lead Compounds for Protein–Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists

Anna Czarna, Barbara Beck, Stuti Srivastava, Grzegorz M. Popowicz, Siglinde Wolf, Yijun Huang, Michal Bista, Tad A. Holak, Alexander Dömling

Journal:

Angewandte Chemie

Year:

2010

Language:

english

File:

PDF, 911 KB

english, 2010

8

Jetzt wird es ernst: strukturbasiertes Design von Mdm2/Mdmx-p53-Inhibitoren

Dr. Grzegorz M. Popowicz, Prof. Alexander Dömling, Dr. Tad A. Holak

Journal:

Angewandte Chemie

Year:

2011

Language:

german

File:

PDF, 811 KB

german, 2011

9

Robust Generation of Lead Compounds for Protein–Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists

Anna Czarna, Barbara Beck, Stuti Srivastava, Grzegorz M. Popowicz, Siglinde Wolf, Yijun Huang, Michal Bista, Tad A. Holak, Alexander Dömling

Journal:

Angewandte Chemie International Edition

Year:

2010

Language:

english

File:

PDF, 929 KB

english, 2010

10

The Structure-Based Design of Mdm2/Mdmx–p53 Inhibitors Gets Serious

Dr. Grzegorz M. Popowicz, Prof. Alexander Dömling, Dr. Tad A. Holak

Journal:

Angewandte Chemie International Edition

Year:

2011

Language:

english

File:

PDF, 808 KB

english, 2011

11

Efforts towards the Design of ‘Teflon’ Proteins: In vivo Translation with Trifluorinated Leucine and Methionine Analogues

Nediljko Budisa, Olga Pipitone, Igor Siwanowicz, Marina Rubini, Prajna Paramita Pal, Tad A. Holak, Maria Luisa Gelmi

Journal:

Chemistry & Biodiversity

Year:

2004

Language:

english

File:

PDF, 195 KB

english, 2004

12

Structural Ramification for Acetyl-Lysine Recognition by the Bromodomain of Human BRG1 Protein, a Central ATPase of the SWI/SNF Remodeling Complex

Mahavir Singh, Grzegorz M. Popowicz, Marcin Krajewski, Tad A. Holak

Journal:

Year:

2007

Language:

english

File:

PDF, 608 KB

english, 2007

13

ChemInform Abstract: The Structure-Based Design of Mdm2/Mdmx—p53 Inhibitors Gets Serious

Grzegorz M. Popowicz, Alexander Doemling, Tad A. Holak

Journal:

Year:

2011

File:

PDF, 18 KB

2011

14

Isoquinolin-1-one Inhibitors of the MDM2–p53 Interaction

Ulli Rothweiler, Anna Czarna, Marcin Krajewski, Jolanta Ciombor, Cédric Kalinski, Vladimir Khazak, Günther Ross, Natalia Skobeleva, Lutz Weber, Tad A. Holak

Journal:

Year:

2008

Language:

english

File:

PDF, 827 KB

english, 2008

15

Exhaustive Fluorine Scanning toward Potent p53–Mdm2 Antagonists

Yijun Huang, Siglinde Wolf, Dr. David Koes, Grzegorz M. Popowicz, Prof. Carlos J. Camacho, Prof. Tad A. Holak, Prof. Alexander Dömling

Journal:

Year:

2012

Language:

english

File:

PDF, 678 KB

english, 2012

16

An Adiabatic Multiple Spin–Echo Pulse Sequence: Removal of Systematic Errors Due to Pulse Imperfections and Off-Resonance Effects

Markus Zweckstetter, Tad A. Holak

Journal:

Journal of Magnetic Resonance

Year:

1998

Language:

english

File:

PDF, 305 KB

english, 1998

17

Separation of Anisotropy and Exchange Broadening Using 15N CSA–15N–1H Dipole–Dipole Relaxation Cross-Correlation Experiments

Christian Renner, Tad A Holak

Journal:

Journal of Magnetic Resonance

Year:

2000

Language:

english

File:

PDF, 142 KB

english, 2000

18

Analytical Solution to the Lipari–Szabo Model Based on the Reduced Spectral Density Approximation Offers a Novel Protocol for Extracting Motional Parameters

Christian Renner, Luis Moroder, Tad A. Holak

Journal:

Journal of Magnetic Resonance

Year:

2001

Language:

english

File:

PDF, 193 KB

english, 2001

19

Secondary NOE pathways in 2D NOESY spectra of proteins estimated from homonuclear three-dimensional NOE-NOE nuclear magnetic resonance spectroscopy

Judith Habazettl, Alfred Ross, Hartmut Oschkinat, Tad A Holak

Journal:

Journal of Magnetic Resonance (1969)

Year:

1969

Language:

english

File:

PDF, 671 KB

english, 1969

20

NMR and mass spectrometry studies of putative interactions of cell cycle proteins pRb and CDK6 with cell differentiation proteins MyoD and ID-2

Pawel Smialowski, Mahavir Singh, Aleksandra Mikolajka, Sudipta Majumdar, Joma K. Joy, Narasimharao Nalabothula, Marcin Krajewski, Roland Degenkolbe, Hans-Ulrich Bernard, Tad A. Holak

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2005

Language:

english

File:

PDF, 604 KB

english, 2005

21

Purification, crystallization, NMR spectroscopy and biochemical analyses of α-phycoerythrocyanin peptides

Georg Wiegand, Axel Parbel, Markus H. J. Seifert, Tad A. Holak, Wolfgang Reuter

Journal:

Year:

2002

Language:

english

File:

PDF, 272 KB

english, 2002

22

NMR 15N relaxation of the insulin-like growth factor (IGF)-binding domain of IGF binding protein-5 (IGFBP-5) determined free in solution and in complex with IGF-II

Christian Renner, Tad A. Holak

Journal:

Year:

2001

Language:

english

File:

PDF, 640 KB

english, 2001

23

NMR characterization of structure, backbone dynamics, and glutathione binding of the human macrophage migration inhibitory factor (MIF)

Peter Mühlhahn, Michael Czisch, Julia Georgescu, Christian Renner, Alfred Ross, Tad A. Holak, Jürgen Bernhagen, Richard Bucala

Journal:

Protein Science

Year:

1996

Language:

english

File:

PDF, 4.12 MB

english, 1996

24

Efficient methods for obtaining phase-sensitive gradient-enhanced HMQC spectra

Alfred Ross, Michael Czisch, Christian Cieslar, Tad A. Holak

Journal:

Journal of Biomolecular NMR

Year:

1993

Language:

english

File:

PDF, 524 KB

english, 1993

25

Computer-assisted assignment of multidimensional NMR spectra of proteins: Application to 3D NOESY-HMQC and TOCSY-HMQC spectra

Reimond Bernstein, Christian Cieslar, Alfred Ross, Hartmut Oschkinat, Jens Freund, Tad A. Holak

Journal:

Journal of Biomolecular NMR

Year:

1993

Language:

english

File:

PDF, 418 KB

english, 1993

26

Mutational analysis of the putative nucleic acid-binding surface of the cold-shock domain, CspB, revealed an essential role of aromatic and basic residues in binding of single-stranded DNA containing the Y-box motif

Katja Schröder, Peter Graumann, Arndt Schnuchel, Tad A. Holak, Mohamed A. Marahiel

Journal:

Molecular Microbiology

Year:

1995

Language:

english

File:

PDF, 2.91 MB

english, 1995

27

1,4-Thienodiazepine-2,5-diones via MCR (I): Synthesis, Virtual Space and p53-Mdm2 Activity

Yijun Huang, Siglinde Wolf, Michal Bista, Lidio Meireles, Carlos Camacho, Tad A. Holak, Alexander Dömling

Journal:

Chemical Biology & Drug Design

Year:

2010

Language:

english

File:

PDF, 667 KB

english, 2010

28

Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site

Mühlhahn, Peter, Zweckstetter, Markus, Georgescu, Julia, Ciosto, Cornelia, Renner, Christian, Lanzendörfer, Martin, Lang, Kurt, Ambrosius, Dorothee, Baier, Michael, Kurth, Reinhard, Holak, Tad A.

Journal:

Natural Structural Biology

Year:

1998

Language:

english

File:

PDF, 826 KB

english, 1998

29

10.1038/74092

Holak, Tad A., Avilés, Francesc X., Reverter, David, Fernández-Catalán, Carlos, Baumgartner, Roland, Pfänder, Ruth, Huber, Robert, Bode, Wolfram, Vendrell, Josep

Journal:

Natural Structural Biology

Year:

2000

Language:

english

File:

PDF, 833 KB

english, 2000

30

Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing

Mishra, Shravan Kumar, Ammon, Tim, Popowicz, Grzegorz M., Krajewski, Marcin, Nagel, Roland J., Ares, Manuel, Holak, Tad A., Jentsch, Stefan

Journal:

Year:

2011

Language:

english

File:

PDF, 657 KB

english, 2011

31

Lifeact: a versatile marker to visualize F-actin

Werb, Zena, Riedl, Julia, Crevenna, Alvaro H, Kessenbrock, Kai, Yu, Jerry Haochen, Neukirchen, Dorothee, Bista, Michal, Bradke, Frank, Jenne, Dieter, Holak, Tad A

Journal:

Year:

2008

Language:

english

File:

PDF, 490 KB

english, 2008

32

The repeating segments of the F-actin cross-linking gelation factor (ABP-120) have an immunoglobulin-like fold

Fucini, Paola, Renner, Christian, Herberhold, Christoph, Noegel, Angelika A., Holak, Tad A.

Journal:

Natural Structural Biology

Year:

1997

File:

PDF, 1.04 MB

1997

33

The crystal structure of the non-liganded 14-3-3σ protein: insights into determinants of isoform specific ligand binding and dimerization

BENZINGER, Anne, POPOWICZ, Grzegorz M, JOY, Joma K, MAJUMDAR, Sudipta, HOLAK, Tad A, HERMEKING, Heiko

Journal:

Year:

2005

Language:

english

File:

PDF, 3.37 MB

english, 2005

34

Letter to the Editor: Sequence-specific 1H, 13C, and 15N assignment of the human melanoma inhibitory activity (MIA) protein

Raphael Stoll, Christian Renner, Dorothee Ambrosius, Michaela Golob, Wolfgang Voelter, Reinhard Buettner, Anja-Katrin Bosserhoff, Tad A. Holak

Journal:

Journal of Biomolecular NMR

Year:

2000

Language:

english

File:

PDF, 34 KB

english, 2000

35

Robust refocusing of 13C magnetization in multidimensional NMR experiments by adiabatic fast passage pulses

Markus Zweckstetter, Tad A. Holak

Journal:

Journal of Biomolecular NMR

Year:

1999

Language:

english

File:

PDF, 67 KB

english, 1999

36

Letter to the Editor: Sequence-specific 1H, 15N, and 13C assignment of the N-terminal domain of the human oncoprotein MDM2 that binds to p53

Raphael Stoll, Christian Renner, Peter Mühlhahn, Silke Hansen, Ralf Schumacher, Friederike Hesse, Brigitte Kaluza, Richard A. Engh, Wolfgang Voelter, Tad A. Holak

Journal:

Journal of Biomolecular NMR

Year:

2000

Language:

english

File:

PDF, 33 KB

english, 2000

37

Practical aspects of the 2D15N-{1H}-NOE experiment

Christian Renner, Michael Schleicher, Luis Moroder, Tad A. Holak

Journal:

Journal of Biomolecular NMR

Year:

2002

Language:

english

File:

PDF, 261 KB

english, 2002

38

Letter to the Editor: Sequence-specific (1H,15N,13C) resonance assignment of the N-terminal domain of the cyclase-associated protein (CAP) fromDictyostelium discoideum

Till Rehm, Chrystelle Mavoungou, Lars Israel, Michael Schleicher, Tad A. Holak

Journal:

Journal of Biomolecular NMR

Year:

2002

Language:

english

File:

PDF, 59 KB

english, 2002

39

Letter to the Editor: Backbone HN, N, Cαand Cβassignment of the GFPuv mutant

Julia Georgescu, Till Rehm, Jens Wiehler, Boris Steipe, Tad A. Holak

Journal:

Journal of Biomolecular NMR

Year:

2003

Language:

english

File:

PDF, 69 KB

english, 2003

40

A novel medium for expression of proteins selectively labeled with15N-amino acids inSpodoptera frugiperda(Sf9) insect cells

Michael Brüggert, Till Rehm, Sreejesh Shanker, Julia Georgescu, Tad A. Holak

Journal:

Journal of Biomolecular NMR

Year:

2003

Language:

english

File:

PDF, 344 KB

english, 2003

41

Letter to the Editor:1H,15N and13C NMR Resonance Assignments of Staphostatin A, a SpecificStaphylococcus AureusCysteine Proteinase Inhibitor

Grzegorz Dubin, Grzegorz Popowicz, Marcin Krajewski, Jan Potempa, Adam Dubin, Tad A. Holak

Journal:

Journal of Biomolecular NMR

Year:

2004

Language:

english

File:

PDF, 81 KB

english, 2004

42

NMR structural characterization of the N-terminal domain of the adenylyl cyclase-associated protein (CAP) fromDictyostelium discoideum

Chrystelle Mavoungou, Lars Israel, Till Rehm, Dorota Ksiazek, Marcin Krajewski, Grzegorz Popowicz, Angelika A. Noegel, Michael Schleicher, Tad A. Holak

Journal:

Journal of Biomolecular NMR

Year:

2004

Language:

english

File:

PDF, 915 KB

english, 2004

43

The p53-MDM2/MDMX axis – A chemotype perspective

Khoury, Kareem, Popowicz, Grzegorz M., Holak, Tad A., Dömling, Alexander

Journal:

Year:

2011

Language:

english

File:

PDF, 710 KB

english, 2011

44

Rapid and Efficient Hydrophilicity Tuning of p53/mdm2 Antagonists

Srivastava, Stuti, Beck, Barbara, Wang, Wei, Czarna, Anna, Holak, Tad A., Dömling, Alexander

Journal:

Journal of Combinatorial Chemistry

Year:

2009

Language:

english

File:

PDF, 4.92 MB

english, 2009

45

Backbone dynamics of the human MIA protein studied by 15N NMR relaxation: Implications for extended interactions of SH3 domains

Raphael Stoll, Christian Renner, Reinhard Buettner, Wolfgang Voelter, Anja-Katrin Bosserhoff, Tad A. Holak

Journal:

Protein Science

Year:

2003

Language:

english

File:

PDF, 574 KB

english, 2003

46

Structural Basis for the Regulation of Insulin-like Growth Factors by IGF Binding Proteins

Igor Siwanowicz, Grzegorz M. Popowicz, Magdalena Wisniewska, Robert Huber, Klaus-Peter Kuenkele, Kurt Lang, Richard A. Engh, Tad A. Holak

Journal:

Year:

2005

Language:

english

File:

PDF, 776 KB

english, 2005

47

NMR Structural Characterization and Computational Predictions of the Major Intermediate in Oxidative Folding of Leech Carboxypeptidase Inhibitor

Joan L. Arolas, Loyola D’Silva, Grzegorz M. Popowicz, Francesc X. Aviles, Tad A. Holak, Salvador Ventura

Journal:

Year:

2005

Language:

english

File:

PDF, 436 KB

english, 2005

48

Filamins: promiscuous organizers of the cytoskeleton

Grzegorz M. Popowicz, Michael Schleicher, Angelika A. Noegel, Tad A. Holak

Journal:

Trends in Biochemical Sciences

Year:

2006

Language:

english

File:

PDF, 9.37 MB

english, 2006

49

Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases

Thomas Weber, Roland Baumgartner, Christian Renner, Mohamed A Marahiel, Tad A Holak

Journal:

Year:

2000

Language:

english

File:

PDF, 491 KB

english, 2000

50

Application of NMR in Structural Proteomics: Screening for Proteins Amenable to Structural Analysis

Till Rehm, Robert Huber, Tad A Holak

Journal:

Year:

2002

Language:

english

File:

PDF, 175 KB

english, 2002

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